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Description:Advanced Search Abstract Pre-eclampsia is the leading cause of fetal and maternal morbidity and mortality. Early onset pre-eclampsia EOPE is a disorder that has severe maternal and fetal outcomes, whilst its etiology is poorly understood. We hypothesize that epigenetics plays an important role to mediate the development of EOPE and conducted a case—control study to compare the genome-wide methylome difference between chorioamniotic membranes from 30 EOPE and 17 full-term pregnancies using the Infinium Human Methylation BeadChip arrays. Bioinformatics analysis tested differential methylation DM at CpG site level, gene level, and pathway and network level. A striking genome-wide hypermethylation pattern coupled with hypomethylation in promoters was observed. Out of CpG sites, showed DM 2.